Multiple Sequence Alignment:
GSDMD Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390       400       410       420       430       440       450       460       470       480       490    )
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GSDMD human MGSAFERVVRRVVQELD-HGGEFIPVTSLQSSTGFQPyCLVVRkPSSSWFWkPRYkCVNLSIkDILEPDAAEPDVQRGRsFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSLSVDPNTWQTLLHERHLRQPEHkVLQQLRsRGDNVyVVtEVLQTQkEVEVTRTHKREGsGRFsLPGATCLQGEGQGHLsQkkTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKkQRTFQPPATGHk
RStsEGAWPQLPsGLSMMRCLH------NFLTDGVPAEGAFT-EDFQGLRAEVETISkELELLDRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLG-PVEPLDGPAGAVLECLVLSSGMLVPELAIPVVYLLGALTMLSETQHKLLA-EALESQTLLGPLELVGSLLEQSAPWQERSTMSLPPGLLGNSWGEGAPAWVLLDECGLELGEDTPHVCWEPQAQGRMCALYASLALLSGLSQEPH
GSDMD mouse MPSAFEKVVKNVIKEVSGSRGDLIPVDSLRNSTSFRPYCLLNRKFsSSRFWKPRYsCVNLSIKDILEPSAPEPEPECFGSFKVSDVVDGNIQGRVMLSGMGEGKISGGAAVSDSSSASMNVCILRVTQKTWETMQHERHLQQPENkILQQLRSRGDDLFVVTEVLQTKEEVQITEVHSQEGSGQFTLPGALCLKGEGKGHQSRKKMVTIPAGSILAFRVAQLLIGSKWDILLVSDEKQRTFE-PSSGDR-----KAVGQRHHGLNVLAALCsIGKQLSLLSDGIDEEELIEAADFQGLYAEVKACSSELESLEMELRQQILVNIGKILQDQPSMEALEASLGQGLCSGGQVEPLDGPAGCILECLVLDSGELVPELAAPIFYLLGALAVLSETQQQLLA-KALETTVLSkQLELVKHVLEQSTPWQEQSSVSLPTVLLGDCWDEKNPTWVLLEECGLRLQVESPQVHWEPTSLIPTSALYASLFLLSSLGQKPC
GSDMD rat MPSAFAGVVKNVIKEVGGSGGELIPVDCLRNSTSFKPYCLLSRKLSSSWFWKPRYTCVNLSIKDILEPSAPEP-------------------------------------VSGSSSASMNVCMLRVTQQTWEIMQRERHLQQPENKILQQLRNRGDDVFVVTEVLQTKEEVQITQVHSHEGSGQFTLPGASCLQGEGKGHQSRKKMVTIPAGSILAFRVAQLLIGSEWDILLISNEKKRTFELPSSGHK-----GAVGQRRHDFSLLAVLHSIGERLSLKSDGTNEEEVIR-EDFQGLRAEVEAGSSELRSLEMELRQQLLVDIGRILQDQPSMEALEASLEQGLCSGEQVEPLEGPAGSILECLVLDSGELVPELAAPVFYLLGALAGLSETQQQLLATKALEATVLSKELELVKHVLEQSTPWQEQRSVPLPSRLLGDSWDEEALTWVLLEECGLTLQVEPPQVYWEPTSQGPICALYASLALLSSLGQKSC
  *:***:.**::*::*:.:::*::***::*::**:*.****:.**.***:******.************:*:**......::...:..::.:::.:.:...:..::.::::**:***:****:.*:*::.**:::::****:***:*:*****:***:::********::**::*.:*:.****:*:****.**:***:**:*:**:****:**:********:*:*.:*:**.:::*:***:.*::*::.....:*::*:.::::.:::*::::..:::::**..:*:::..:*****:***::.*:**::*::**:*::*:.::.:*:**::::***::*:**:::*.:****:****::******:**:******:*::******:.*****::***.:***:::*::.****:::****:****:::::**..***::*:*.:::****:****.*:::.*:*.***:::::.:******:***:*:*:::
Consensus MPSAFERVVKNVIKEVDGSGGELIPVDSLRNSTSFRPYCLLNRKLSSSWFWKPRYKCVNLSIKDILEPSAPEPDPQRGRSFHFSDAMDGNIQGRVELAAMGQAKIAGGAAVSDSSSASMNVCILRVTQNTWETMQHERHLQQPENKILQQLRSRGDDVFVVTEVLQTKEEVQITRVHSREGSGQFTLPGALCLQGEGKGHQSRKKMVTIPAGSILAFRVAQLLIGSDWDILLISDEKQRTFELPSSGHK-----GAVGQRRHGLSLLAALHSIGERLSLLSDGINEEEAIR-EDFQGLRAEVEACSSELESLEMELRQQLLVNIGRILQDQPSMEALEASLEQGLCSGEQVEPLDGPAGAILECLVLDSGELVPELAAPVFYLLGALAGLSETQQQLLA-KALEATVLSKQLELVKHVLEQSTPWQEQSSVSLPPRLLGDSWDEEAPTWVLLEECGLRLQVEPPQVCWEPTSQGPICALYASLALLSSLGQKPC
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using MAFFT. Conservation and consensus calculated using von Neumann entropy from PFAAT.