Multiple Sequence Alignment:
IST1 Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360        )
           |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |        
IST1 human MLGsGFkAERLRVNLRLVINRLKLLEKKKTELAQkARkEIADyLAAGkDERARIRVEHIIREDYLVEAMEILELYCDLLLARFGLIQsMKELDSGLAESVSTLIWAAPRLQsEVAELkIVADQLCAkYSKEYGkLCRTNQIGTVNDrLMHkLsVEAPPkILVERYLIEIAKNYNVPYEPDSVVMAEAPPGVETDLIdVGFTDDVkkGGPGRGGsGGFTAPVGGPDGTVPMPMP--M--PMPSANTPFSYPLPkGPSDFNGLPMGTYQAFPNIHPPQIPAtPPsYESVDDINADKNIssAQIVGPGPkPEAsAkLPSRPADNYDNFVLPELPSVPDTLPtAsAGASTSASEDIDFDDLSRRFEELkKKT
IST1 iso2 human MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGrGGsGGFTAPVGGPDGTVPMPMPMPM--PMPSANTPFSYPLPKGP-------------------------------VDDINADKNISSAQIVGPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFEELKKKT
IST1 mouse MLGsGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADyLAAGkDERARIRVEHIIREDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAkYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPDSVVMAEAPVGVETDLIDVGFTDDVKKGGPGRGGGGGFtAPVGGPDGIVPMPMPMP----MPsPNAPFAyPLPKGPSDFSGLPVGTYQAFPNIHPPQIPAtPPSYESVDDINGDKTVSSAQIVGP--KPEAPAKPPSRPVDNYNTFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFEELKKKT
IST1 rat MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADyLAAGkDERARIRVEHIIREDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPDSVVMAEAPVGVETDLIDVGFTDDVKKGGPGRGGGGGFTAPVGAPDGTMPMPMPMPMPMPSPSPNAPFAYPLPKGPSDFSGLPVGTYQAFPNIHPPQIPATPPSYESVDDINADKNVSSAQIVGP--KPEAPAKPPSRPVDNYNTFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFEELkKKT
  ********************************************************************************************************************************************************************************************:************************:********:***::*****:::  ::**:*:**:*******:::.:::.:::::::::::::::::::::::*****:**::********..****:**:****:***::********************************************
Consensus MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGGGGFTAPVGGPDGTVPMPMPMPM--PMPSANAPFAYPLPKGPSDFSGLPVGTYQAFPNIHPPQIPATPPSYESVDDINADKNISSAQIVGPGPKPEAPAKLPSRPADNYNNFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFEELKKKT
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.