Multiple Sequence Alignment:
SIRT6 Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350     )
           |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |     
SIRT6 human MSVNYAAGLsPYADKGkCGLPEIFDPPEELERk
VWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPkFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDk
LAELHGNMFVEECAKCKtQyVRDTVVGTMGLk
AtGRLCTVAkARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTkHDRHADLRIHGYVDEVMTRLMk
HLGLEIPAWDGPRVLERALPPLPRPPtPKLEPKEEsPtRINGsIPAGPKQEPCAQHNGsEPAsPKRERPtsPAPHRPPKRVKAKAVPS
SIRT6 iso2 human MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACR---------------------------NADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS
SIRT6 mouse MSVNYAAGLsPYADKGKCGLPEIFDPPEELERKVWELARLMWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFENARPSKTHMALVQLERMGFLSFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECPKCKTQYVRDTVVGTMGLKATGRLCTVAKTRGLRACRGELRDTILDWEDSLPDRDLMLADEASRTADLSVTLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRQADLRIHGYVDEVMCRLMKHLGLEIPAWDGPCVLDKALPPLPRPVALKAEP----PVHLNGAVHVSYKSK-----------------PNSPILHRPPKRVKTEAAPS
SIRT6 rat MSVNYAAGLSPYADKGKCGLPEIFDPPEELECKVWELARLMWQSSTVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDITFENARPSKTHMALVQLERMGFLSFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECPKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDALPDRDLTLADEASRTADLSVTLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRQADLCIHGYVDEVMCKLMKHLGLEIPTWDGPRVLEKALPPLPRPVAPKAEP----PVHLNG----SYKPK-----------------PDSPVPHRPPKRVKTEAAAS
  *******************************:********:****:*************************************:***:***::**********:*:*:*********************************:****************************:*******:::::::::::::::::::.::::::::****:*************************************:***:*********::**********:****:**::********:::*:**....*:::**:...::*.:.................*.**::********::*::*
Consensus MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLMWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFENARPSQTHMALVQLERMGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRQADLRIHGYVDEVMCRLMKHLGLEIPAWDGPRVLERALPPLPRPPAPKAEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAEAAPS
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.