Multiple Sequence Alignment:
APOBEC3B Download MSA
  (        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390       400       410       420       430       440       450       460    )
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APOBEC3B human MNPQIR-------------------NPME-RMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRsNLLWDTGVFRGQVYFKPQYHAEMCFLSWFCGNQLP---AYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCrLSQAGARVTIMDYEEFAYCWENFVYNEGQQFMPWYKFDENyAFLHRTLKEILRyLMDPDTFTFNFNNDPL---------------------------------------VLRRRQTYLCYEVERLDNGTWVLMDQHMGFLCNEAkNLLCGFYGRHA--ELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIy-DyDPLykEALQMLRDAGAQVsIMTYDEFEYCWDTFVYRQGCPFQPWDGLEEHSQALSGRLRAILQNQGN-----------------
APOBEC3B iso2 human MNPQIR-------------------NPME-RMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVYFKPQYHAEMCFLSWFCGNQLP---AYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVTIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAFLHRTLKEILRLRIFSVAFTAAMRSC---------------------------------------------------------ASWTWFLL-------CSWTRPRSTGSLGS-----------SPGAPASPGAVPG-------------KC---VRSFRRTHT---------------------------------------------------------------------------------------------------
APOBEC3B iso3 human MNPQIR-------------------NPME-RMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVYFKPQYHAEMCFLSWFCGNQLP---AYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVTIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPL---------------------------------------VLRRRQTYLCYEVERLDNGTWVLMDQHMGFLCNE---------------------------LDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIY-DYDPLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFVYRQGCPFQPWDGLEEHSQALSGRLRAILQNQGN-----------------
APOBEC3B mouse MQPQRLGPRAGMGPFCLGCSHRKCYsPIRNLISQETFKFHFKNLGYAKGRKDTFLCYEVTRKDCDSPVSLHHGVFKN----KDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQIVRFLATHHNLSLDIFSSRLYNVQDPEtQQNLCRLVQEGAQVAAMDLyEFkkCWKKFVDNGGRRFRPWKRLLTNFRYQDSKLQEILRPCYISVPSSSSSTLSNICLTKGLPETRFWVEGRRMDPLSEEEFYSQFYNQRVKHLCyyHRMKPYLCYQLEQFNGQAP------------LKGCLLSEKGKQHA--EILFLDKIRsMELsQ---VTITCYLTWSPCP--NCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVNP-KRPFWPWKGLEIISRRTQRRLRRIKESWGLQDLVNDFGNLQLGPPMS
APOBEC3B iso2 mouse -----------MGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLGYAKGRKDTFLCYEVTRKDCDSPVSLHHGVFKN----KDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQIVRFLATHHNLSLDIFSSRLYNVQDPETQQNLCRLVQEGAQVAAMDLYEFKKCWKKFVDNGGRRFRPWKRLLTNFRYQDSKLQEILRPCYIPVPSSSSSTLSNICLTKGLPETRFCVEGRRMDPLSEEEFYSQFYNQRVKHLCYYHRMKPYLCYQLEQFNGQAP------------LKGCLLSEKGKQHA--EILFLDKIRSMELSQ---VTITCYLTWSPCP--NCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVNP-KRPFWPWKGLEIISRRTQRRLRRIKEVRTTLL---------QGPAS-
APOBEC3B iso3 mouse -----------MGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLGYAKGRKDtFLCYEVTRKDCDSPVSLHHGVFKN----KDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQIVRFLATHHNLSLDIFsSRLYNVQDPETQQNLCRLVQEGAQVAAMDLYEFKKCWKKFVDNGGRRFRPWKRLLTNFRYQDSKLQEIL---------------------------------RRMDPLSEEEFYSQFYNQRVKHLCYYHRMKPYLCYQLEQFNGQAP------------LKGCLLSEKGKQHA--EILFLDKIRSMELSQ---VTITCYLTWSPCP--NCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVNP-KRPFWPWKGLEIISRRTQRRLRRIKESRSHAS---------------
APOBEC3B iso4 mouse -----------MGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLGYAKGRKDTFLCYEVTRKDCDSPVSLHHGVFKN----KDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQIVRFLATHHNLSLDIFSSRLYNVQDPETQQNLCRLVQEGAQVAAMDLYEFKKCWKKFVDNGGRRFRPWKRLLTNFRYQDSKLQEIL---------------------------------RRMDPLSEEEFYSQFYNQRVKHLCYYHRMKPYLCYQLEQFNGQAP------------LKGCLLSEKGKQHA--EILFLDKIRSMELSQ---VTITCYLTWSPCP--NCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVNP-KRPFWPWKGLEIISRRTQRRLRRIKESWGLQDLVNDFGNLQLGPPMS
APOBEC3B iso5 mouse ------------------------------------------------------------------------------------------------------------MGHLFAESWRLWALCGVELSRAVDTIPPEALLTS--PLILAVDG----------------------------------------------------------------------------------------------------------------------------------------------HTQGSSAGVKSCLYSRAGQAIERtKQCMLSALPVSSLSG----------VQSPCK---CASAS-----------------------------------------------------------------------------------------------------------
APOBEC3B rat -----------MGPFCLGCSHRKCYsPIRNLISQETFKFHFKNLRYAIDRKDTFLCYEVTRKDCDSPVSLHHGVFKN----KDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQVLRFLATHHNLSLDIFSSRLYNIRDPENQQNLCRLVQEGAQVAAMDLYEFKKCWKKFVDNGGRRFRPWKKLLTNFRYQDSKLQEILRPCYIPVPSSSSSTLSNICLTKGLPETRFCVERRRVHLLSEEEFYSQFYNQRVKHLCYYHGVKPYLCYQLEQFNGQAP------------LKGCLLSEKGKQHA--EILFLDkIRSMELSQ---VIITCYLTWSPCP--NCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVNP-KRPFWPWKGLEIISRRTQRRLHRIKESWGLQDLVNDFGNLQLGPPMS
  ......     ..............::::.::::::::::::::.::.:::::::::::::::::::::::::::::....::::::::::::::::::::...:::::::::::**:::::*:::::::::::::::*::::::*:::.:::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::............................ .. ...........................:...::::..:..:..:: .     .  . .:.::::..:..::  :..:::..::..:::   ...:....::::.  .*:.:::::.:..:...:.:.:::.:.........::..:..:::.:..:....:..::..::.. ..::.::.:::..:.:...:::::.......................
Consensus -----------MGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLGYAKGRKDTFLCYEVTRKDCDSPVSLHHGVFKN----KDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQIVRFLATHHNLSLDIFSSRLYNVQDPETQQNLCRLVQEGAQVAAMDLYEFKKCWKKFVDNGGRRFRPWKRLLTNFRYQDSKLQEILRPCYIPVPFSSSSTLS-----------------RRMDPLSEEEFYSQFYNQRVKHLCYYHRMKPYLCYQLEQFNGQAP------------LKGCLLSEKGKQHA--EILFLDKIRSMELSQ---VTITCYLTWSPCP--NCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVNP-KRPFWPWKGLEIISRRTQRRLRRIKESWGL-----------------
Modified residues are boxed in RED. Mouse-over modified sites to view residue numbers.
Aligned using Clustal Omega. Conservation and consensus calculated using von Neumann entropy from PFAAT.