(        10        20        30        40        50        60        70        80        90       100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390       400       410       420       430       440       450       460    )
	|         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |         |
APOBEC3B human	MNPQIR-------------------NPME-RMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRsNLLWDTGVFRGQVYFKPQYHAEMCFLSWFCGNQLP---AYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCrLSQAGARVTIMDYEEFAYCWENFVYNEGQQFMPWYKFDENyAFLHRTLKEILRyLMDPDTFTFNFNNDPL---------------------------------------VLRRRQtYLCYEVERLDNGTWVLMDQHMGFLCNEAkNLLCGFYGRHA--ELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIy-DyDPLykEALQMLRDAGAQVsIMTYDEFEYCWDTFVYRQGCPFQPWDGLEEHSQALSGRLRAILQNQGN-----------------
APOBEC3B iso2 human	MNPQIR-------------------NPME-RMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVYFKPQYHAEMCFLSWFCGNQLP---AYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVTIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAFLHRTLKEILRLRIFSVAFTAAMRSC---------------------------------------------------------ASWTWFLL-------CSWTRPRSTGSLGS-----------SPGAPASPGAVPG-------------KC---VRSFRRTHT---------------------------------------------------------------------------------------------------
APOBEC3B iso3 human	MNPQIR-------------------NPME-RMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVYFKPQYHAEMCFLSWFCGNQLP---AYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVTIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPL---------------------------------------VLRRRQTYLCYEVERLDNGTWVLMDQHMGFLCNE---------------------------LDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIY-DYDPLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFVYRQGCPFQPWDGLEEHSQALSGRLRAILQNQGN-----------------
APOBEC3B mouse	MQPQRLGPRAGMGPFCLGCSHRKCYsPIRNLISQETFKFHFKNLGYAKGRKDTFLCYEVTRKDCDSPVSLHHGVFKN----KDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQIVRFLATHHNLSLDIFSSRLYNVQDPEtQQNLCRLVQEGAQVAAMDLyEFkkCWKKFVDNGGRRFRPWKRLLtNFRYQDSKLQEILRPCYISVPSSSSSTLSNICLTKGLPETRFWVEGRRMDPLSEEEFYSQFYNQRVKHLCyyHRMKPYLCYQLEQFNGQAP------------LKGCLLSEKGKQHA--EILFLDKIRsMELsQ---VTITCYLTWSPCP--NCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVNP-KRPFWPWKGLEIISRRTQRRLRRIKESWGLQDLVNDFGNLQLGPPMS
APOBEC3B iso2 mouse	-----------MGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLGYAKGRKDTFLCYEVTRKDCDSPVSLHHGVFKN----KDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQIVRFLATHHNLSLDIFSSRLYNVQDPETQQNLCRLVQEGAQVAAMDLYEFKKCWKKFVDNGGRRFRPWKRLLTNFRYQDSKLQEILRPCYIPVPSSSSSTLSNICLTKGLPETRFCVEGRRMDPLSEEEFYSQFYNQRVKHLCYYHRMKPYLCYQLEQFNGQAP------------LKGCLLSEKGKQHA--EILFLDKIRSMELSQ---VTITCYLTWSPCP--NCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVNP-KRPFWPWKGLEIISRRTQRRLRRIKEVRTTLL---------QGPAS-
APOBEC3B iso3 mouse	-----------MGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLGYAKGRKDtFLCYEVTRKDCDSPVSLHHGVFKN----KDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQIVRFLATHHNLSLDIFsSRLYNVQDPETQQNLCRLVQEGAQVAAMDLYEFKKCWKKFVDNGGRRFRPWKRLLTNFRYQDSKLQEIL---------------------------------RRMDPLSEEEFYSQFYNQRVKHLCYYHRMKPYLCYQLEQFNGQAP------------LKGCLLSEKGKQHA--EILFLDKIRSMELSQ---VTITCYLTWSPCP--NCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVNP-KRPFWPWKGLEIISRRTQRRLRRIKESRSHAS---------------
APOBEC3B iso4 mouse	-----------MGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLGYAKGRKDTFLCYEVTRKDCDSPVSLHHGVFKN----KDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQIVRFLATHHNLSLDIFSSRLYNVQDPETQQNLCRLVQEGAQVAAMDLYEFKKCWKKFVDNGGRRFRPWKRLLTNFRYQDSKLQEIL---------------------------------RRMDPLSEEEFYSQFYNQRVKHLCYYHRMKPYLCYQLEQFNGQAP------------LKGCLLSEKGKQHA--EILFLDKIRSMELSQ---VTITCYLTWSPCP--NCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVNP-KRPFWPWKGLEIISRRTQRRLRRIKESWGLQDLVNDFGNLQLGPPMS
APOBEC3B iso5 mouse	------------------------------------------------------------------------------------------------------------MGHLFAESWRLWALCGVELSRAVDTIPPEALLTS--PLILAVDG----------------------------------------------------------------------------------------------------------------------------------------------HTQGSSAGVKSCLYSRAGQAIERtKQCMLSALPVSSLSG----------VQSPCK---CASAS-----------------------------------------------------------------------------------------------------------
APOBEC3B rat	-----------MGPFCLGCSHRKCYsPIRNLISQETFKFHFKNLRYAIDRKDTFLCYEVTRKDCDSPVSLHHGVFKN----KDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQVLRFLATHHNLSLDIFSSRLYNIRDPENQQNLCRLVQEGAQVAAMDLYEFKKCWKKFVDNGGRRFRPWKKLLTNFRYQDSKLQEILRPCYIPVPSSSSSTLSNICLTKGLPETRFCVERRRVHLLSEEEFYSQFYNQRVKHLCYYHGVKPYLCYQLEQFNGQAP------------LKGCLLSEKGKQHA--EILFLDkIRSMELSQ---VIITCYLTWSPCP--NCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVNP-KRPFWPWKGLEIISRRTQRRLHRIKESWGLQDLVNDFGNLQLGPPMS
	......     ..............::::.::::::::::::::.::.:::::::::::::::::::::::::::::....::::::::::::::::::::...:::::::::::**:::::*:::::::::::::::*::::::*:::.:::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::............................ .. ...........................:...::::..:..:..:: .     .  . .:.::::..:..::  :..:::..::..:::   ...:....::::.  .*:.:::::.:..:...:.:.:::.:.........::..:..:::.:..:....:..::..::.. ..::.::.:::..:.:...:::::.......................
Consensus	-----------MGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLGYAKGRKDTFLCYEVTRKDCDSPVSLHHGVFKN----KDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQIVRFLATHHNLSLDIFSSRLYNVQDPETQQNLCRLVQEGAQVAAMDLYEFKKCWKKFVDNGGRRFRPWKRLLTNFRYQDSKLQEILRPCYIPVPFSSSSTLS-----------------RRMDPLSEEEFYSQFYNQRVKHLCYYHRMKPYLCYQLEQFNGQAP------------LKGCLLSEKGKQHA--EILFLDKIRSMELSQ---VTITCYLTWSPCP--NCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVNP-KRPFWPWKGLEIISRRTQRRLRRIKESWGL-----------------