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HSP27 a small heat shock protein that is regulated both transcriptionally and posttranslationally. Modulates actin polymerization and reorganization. Its expression level increases several-fold in response to stress and is phosphorylated by MAPKAP kinase 2. Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Heat shock protein; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: cytoplasm; cytoskeleton; cytosol; extracellular matrix; extracellular space; focal adhesion; nucleus; proteasome complex
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein kinase binding; protein kinase C binding; protein kinase C inhibitor activity; RNA binding; ubiquitin binding
Biological Process: cell motility; negative regulation of apoptosis; negative regulation of protein kinase activity; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of interleukin-1 beta production; positive regulation of tumor necrosis factor biosynthetic process; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of mRNA stability; regulation of protein amino acid phosphorylation; regulation of translational initiation; response to virus; retinal homeostasis; vascular endothelial growth factor receptor signaling pathway
Disease: Charcot-marie-tooth Disease, Axonal, Type 2f; Neuronopathy, Distal Hereditary Motor, Type Iib
Reference #:  P04792 (UniProtKB)
Alt. Names/Synonyms: 28 kDa heat shock protein; CMT2F; DKFZp586P1322; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; heat shock 27kD protein 1; heat shock 27kDa protein 1; Heat shock protein beta-1; HMN2B; HS.76067; HSP 27; Hsp25; HSP27; HSP28; HSPB1; SRP27; Stress-responsive protein 27
Gene Symbols: HSPB1
Molecular weight: 22,783 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
CST Pathways:  Inhibition of Apoptosis  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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