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Protein Page:

PPM1G is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]
Protein type: EC; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor); Spliceosome
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; protein serine/threonine phosphatase activity
Biological Process: protein amino acid dephosphorylation
Reference #:  O15355 (UniProtKB)
Alt. Names/Synonyms: MGC1675; MGC2870; PP2C, gamma; PP2C-gamma; PP2CG; PP2CGAMMA; PPM1C; PPM1G; PPP2CG; Protein phosphatase 1C; Protein phosphatase 1G; protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform; protein phosphatase 2, catalytic subunit, gamma isoform; protein phosphatase 2C gamma isoform; Protein phosphatase 2C isoform gamma; Protein phosphatase magnesium-dependent 1 gamma; protein phosphatase, Mg2+/Mn2+ dependent, 1G
Gene Symbols: PPM1G
Molecular weight: 59,272 Da
Basal Isoelectric point: 4.28  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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