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AID Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Strongly expressed in lymph nodes and tonsils. Belongs to the cytidine and deoxycytidylate deaminase family. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component: cytoplasm; exosome (RNase complex); nucleus
Molecular Function: cytidine deaminase activity; protein binding; ubiquitin protein ligase binding; zinc ion binding
Biological Process: B cell differentiation; cytidine deamination; defense response to bacterium; isotype switching; mRNA processing; somatic diversification of immunoglobulins; somatic hypermutation of immunoglobulin genes
Disease: Immunodeficiency With Hyper-igm, Type 2
Reference #:  Q9GZX7 (UniProtKB)
Alt. Names/Synonyms: Activation-induced cytidine deaminase; AICDA; AID; ARP2; CDA2; Cytidine aminohydrolase; HIGM2; integrated into Burkitt's lymphoma cell line Ramos
Gene Symbols: AICDA
Molecular weight: 23,954 Da
Basal Isoelectric point: 9.5  Predict pI for various phosphorylation states
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