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SLC26A3 Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon, participating in fluid homeostasis. Defects in SLC26A3 are the cause of diarrhea type 1 (DIAR1); also known as congenital chloride diarrhea (CLD). DIAR1 is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 6q16
Cellular Component: apical plasma membrane; brush border membrane; integral component of plasma membrane; membrane
Molecular Function: anion:anion antiporter activity; bicarbonate transmembrane transporter activity; chloride channel activity; chloride transmembrane transporter activity; oxalate transmembrane transporter activity; secondary active sulfate transmembrane transporter activity; sulfate transmembrane transporter activity
Biological Process: bicarbonate transport; intracellular pH elevation; membrane hyperpolarization; oxalate transport; regulation of intracellular pH; regulation of membrane potential; sperm capacitation
Reference #:  Q924C9 (UniProtKB)
Alt. Names/Synonyms: Chloride anion exchanger; Down-regulated in adenoma; Dra; Protein DRA; S26A3; Slc26a3; Solute carrier family 26 member 3; solute carrier family 26, member 3
Gene Symbols: Slc26a3
Molecular weight: 83,369 Da
Basal Isoelectric point: 8.42  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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