a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two isoforms. Note: This description may include information from UniProtKB.
Cellular Component: apoptosome; cytosol; mitochondrion; nucleus; protein complex
Molecular Function: cysteine-type endopeptidase activity; enzyme activator activity; peptidase activity; protein binding; protein kinase binding; SH3 domain binding
Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; aging; apoptosis; cellular response to dexamethasone stimulus; cellular response to DNA damage stimulus; cellular response to UV; DNA damage response, signal transduction resulting in induction of apoptosis; platelet formation; positive regulation of apoptosis; positive regulation of neuron apoptotic process; protein kinase B signaling; proteolysis; regulation of response to DNA damage stimulus; response to antibiotic; response to cobalt ion; response to estradiol; response to lipopolysaccharide; signal transduction in response to DNA damage