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CASP9 a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two isoforms. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC; Protease
Chromosomal Location of Human Ortholog: 1p36.21
Cellular Component: apoptosome; cytosol; mitochondrion; nucleus; protein complex
Molecular Function: cysteine-type endopeptidase activity; enzyme activator activity; peptidase activity; protein binding; protein kinase binding; SH3 domain binding
Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; aging; apoptosis; cellular response to dexamethasone stimulus; cellular response to DNA damage stimulus; cellular response to UV; DNA damage response, signal transduction resulting in induction of apoptosis; platelet formation; positive regulation of apoptosis; positive regulation of neuron apoptotic process; protein kinase B signaling; proteolysis; regulation of response to DNA damage stimulus; response to antibiotic; response to cobalt ion; response to estradiol; response to lipopolysaccharide; signal transduction in response to DNA damage
Reference #:  P55211 (UniProtKB)
Alt. Names/Synonyms: APAF-3; APAF3; apoptotic protease activating factor 3; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; CASP-9; CASP9; caspase 9, apoptosis-related cysteine peptidase; caspase 9, apoptosis-related cysteine protease; Caspase-9; Caspase-9 subunit p10; Caspase-9 subunit p35; CASPASE-9c; ICE-LAP6; ICE-like apoptotic protease 6; MCH6
Gene Symbols: CASP9
Molecular weight: 46,281 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Apoptosis Regulation  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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