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TrkA a receptor tyrosine kinase of the Trk family. High affinity receptor for nerve growth factor, neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor. Known substrates include Shc, PI-3K, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Trk family
Chromosomal Location of Human Ortholog: 3 F1|3 38.62 cM
Cellular Component: axon; cell soma; cell surface; cytoplasm; cytoplasmic vesicle; dendrite; early endosome; integral to plasma membrane; late endosome; plasma membrane; protein complex; receptor complex
Molecular Function: GPI-linked ephrin receptor activity; kinase binding; nerve growth factor binding; nerve growth factor receptor activity; neurotrophin p75 receptor binding; protein binding; protein homodimerization activity; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process: activation of NF-kappaB transcription factor; axon guidance; B cell differentiation; circadian rhythm; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; learning and/or memory; mechanoreceptor differentiation; negative regulation of cell proliferation; negative regulation of neuron apoptosis; nerve growth factor receptor signaling pathway; nervous system development; peptidyl-tyrosine phosphorylation; positive regulation of angiogenesis; positive regulation of GTPase activity; positive regulation of programmed cell death; positive regulation of protein amino acid phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; protein amino acid autophosphorylation; protein amino acid phosphorylation; response to activity; response to drug; response to electrical stimulus; response to nicotine; response to nutrient levels; sensory perception of pain; Sertoli cell development; sympathetic nervous system development
Reference #:  Q3UFB7 (UniProtKB)
Alt. Names/Synonyms: C80751; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase, receptor, type 1; Ntrk1; Tkr; trk; TrkA
Gene Symbols: Ntrk1
Molecular weight: 87,738 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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