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p67phox NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Interacts with SYTL1 and RAC1. Interacts with NCF4. May interact with NOXO1. Belongs to the NCF2/NOXA1 family. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase
Chromosomal Location of Human Ortholog: 1q25.3
Cellular Component: cytosol; NADPH oxidase complex; nucleolus
Molecular Function: electron carrier activity; protein binding; protein C-terminus binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell redox homeostasis; cellular defense response; innate immune response; respiratory burst; superoxide metabolic process; superoxide release; vascular endothelial growth factor receptor signaling pathway
Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-positive, Type Ii
Reference #:  P19878 (UniProtKB)
Alt. Names/Synonyms: 67 kDa neutrophil oxidase factor; chronic granulomatous disease, autosomal 2; FLJ93058; NADPH oxidase activator 2; NCF-2; NCF2; Neutrophil cytosol factor 2; neutrophil cytosolic factor 2; neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2); Neutrophil NADPH oxidase factor 2; NOXA2; p67-phox; P67PHOX
Gene Symbols: NCF2
Molecular weight: 59,762 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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