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Protein Page:

eIF2-gamma eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: Xp22.11
Cellular Component: cytoplasm; cytosol; eukaryotic translation initiation factor 2 complex; nucleus
Molecular Function: cadherin binding; GTP binding; GTPase activity; protein binding; translation factor activity, nucleic acid binding; translation initiation factor activity
Biological Process: translational initiation; transmembrane transport
Disease: Mental Retardation, X-linked, Syndromic, Borck Type
Reference #:  P41091 (UniProtKB)
Alt. Names/Synonyms: eIF-2-gamma X; eIF-2gA; eIF-2gX; EIF2; EIF2G; EIF2gamma; EIF2S3; Eukaryotic translation initiation factor 2 subunit 3; Eukaryotic translation initiation factor 2 subunit gamma X; eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa; eukaryotic translation initiation factor 2G; IF2G
Gene Symbols: EIF2S3
Molecular weight: 51,109 Da
Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF2  |  Translational Control
Select Structure to View Below


Protein Structure Not Found.

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