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ABCC1 a multi-pass membrane protein. A multidrug resistance member of the ABC transporter family that confers resistance to anticancer drugs. A multi-pass membrane protein. Exports sphingosine-1-phosphate (S1P), a potent inflammatory mediator, from mast cells during mast cell-mediated immune responses. Nine alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family
Chromosomal Location of Human Ortholog: 16|16 A1
Cellular Component: basolateral plasma membrane; cytoplasm; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane
Molecular Function: ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; drug transmembrane transporter activity; efflux transmembrane transporter activity; glutathione S-conjugate-exporting ATPase activity; hydrolase activity; lipid-transporting ATPase activity; long-chain fatty acid transporter activity; nucleotide binding; phospholipid-translocating ATPase activity; sphingolipid transporter activity; sphingolipid-translocating ATPase activity; transporter activity; xenobiotic transmembrane transporting ATPase activity
Biological Process: drug export; drug transmembrane transport; phospholipid efflux; phospholipid translocation; plasma membrane long-chain fatty acid transport; positive regulation of cell migration; response to drug; response to oxidative stress; transmembrane transport; transport; xenobiotic transport
Reference #:  O35379 (UniProtKB)
Alt. Names/Synonyms: Abcc1; Abcc1a; Abcc1b; ATP-binding cassette sub-family C member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1a; ATP-binding cassette, sub-family C (CFTR/MRP), member 1b; Leukotriene C(4) transporter; LTC4 transporter; Mdrap; Mrp; Mrp1; Multidrug resistance-associated protein 1; multiple drug resistance-associated protein
Gene Symbols: Abcc1
Molecular weight: 171,185 Da
Basal Isoelectric point: 7.03  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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