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hnRNP M Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; RNA splicing; RNA-binding; Receptor, misc.; Spliceosome
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: extracellular matrix; integral component of plasma membrane; membrane; nuclear matrix; nucleolus; nucleoplasm; paraspeckles; spliceosomal complex
Molecular Function: protein binding; protein domain specific binding; RNA binding
Biological Process: alternative mRNA splicing, via spliceosome; fibroblast growth factor receptor signaling pathway; mRNA splicing, via spliceosome; RNA metabolic process
Reference #:  P52272 (UniProtKB)
Alt. Names/Synonyms: DKFZp547H118; Heterogeneous nuclear ribonucleoprotein M; heterogenous nuclear ribonucleoprotein M; heterogenous nuclear ribonucleoprotein M4; hnRNA-binding protein M4; hnRNP M; HNRNPM; HNRNPM4; HNRPM; HNRPM4; HTGR1; M4 protein; N-acetylglucosamine receptor 1; NAGR1
Gene Symbols: HNRNPM
Molecular weight: 77,516 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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