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Protein Page:
G-alpha i3

G-alpha i3 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. Defects in GNAI3 are the cause of auriculocondylar syndrome 1 (ARCND1). ARCND1 is an autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia. Belongs to the G-alpha family. G(i/o/t/z) subfamily. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z))
Chromosomal Location of Human Ortholog: 1p13.3
Cellular Component: centrosome; cytoplasm; endoplasmic reticulum membrane; Golgi membrane; heterotrimeric G-protein complex; lysosomal membrane; membrane; membrane raft; midbody; nucleolus; nucleus; plasma membrane
Molecular Function: G-protein beta/gamma-subunit complex binding; G-protein coupled receptor binding; GDP binding; GTP binding; GTPase activating protein binding; GTPase activity; metabotropic serotonin receptor binding; metal ion binding; protein binding; protein domain specific binding; signal transducer activity
Biological Process: cell cycle; cell division; dopamine receptor signaling pathway; G-protein coupled receptor signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; GTP metabolic process; negative regulation of adenylate cyclase activity; positive regulation of macroautophagy; protein folding; transport; vesicle fusion
Disease: Auriculocondylar Syndrome 1
Reference #:  P08754 (UniProtKB)
Alt. Names/Synonyms: 87U6; FLJ26559; G(i) alpha-3; GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3; Guanine nucleotide-binding protein G(k) subunit alpha
Gene Symbols: GNAI3
Molecular weight: 40,532 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Hedgehog Signaling  |  Microtubule Dynamics  |  Parkinson's Disease  |  Phospholipase Signaling  |  PI3K/Akt Signaling
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G-alpha i3

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