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PDX1 Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP. Interacts with the methyltransferase SETD7. Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells). Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 13q12.2
Cellular Component: cytosol; nuclear speck; nucleoplasm
Molecular Function: chromatin binding; DNA binding transcription factor activity
Biological Process: detection of glucose; exocrine pancreas development; generation of precursor metabolites and energy; glucose homeostasis; glucose metabolic process; gut development; insulin secretion; liver development; morphogenesis of embryonic epithelium; negative regulation of cell proliferation; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of type B pancreatic cell apoptotic process; nitric oxide mediated signal transduction; organ morphogenesis; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; type B pancreatic cell differentiation
Disease: Diabetes Mellitus, Noninsulin-dependent; Diabetes Mellitus, Permanent Neonatal; Maturity-onset Diabetes Of The Young, Type 4; Pancreatic Agenesis 1
Reference #:  P52945 (UniProtKB)
Alt. Names/Synonyms: Glucose-sensitive factor; GSF; IDX-1; Insulin promoter factor 1; insulin promoter factor 1, homeodomain transcription factor; Insulin upstream factor 1; IPF-1; IPF1; Islet/duodenum homeobox-1; IUF-1; IUF1; MODY4; Pancreas/duodenum homeobox protein 1; pancreatic and duodenal homeobox 1; pancreatic-duodenal homeobox factor 1; PDX-1; PDX1; somatostatin transcription factor 1; Somatostatin-transactivating factor 1; STF-1
Gene Symbols: PDX1
Molecular weight: 30,771 Da
Basal Isoelectric point: 7.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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