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TAF1B Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3. Belongs to the RRN7/TAF1B family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nucleolus; Transcription initiation complex
Chromosomal Location of Human Ortholog: 2p25.1
Cellular Component: extracellular exosome; nucleoplasm; nucleus; RNA polymerase transcription factor SL1 complex
Molecular Function: DNA binding transcription factor activity; metal ion binding; protein binding; TATA-binding protein binding
Biological Process: positive regulation of gene expression, epigenetic; regulation of transcription, DNA-templated; RNA elongation from RNA polymerase I promoter; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter; transcription, DNA-dependent
Reference #:  Q53T94 (UniProtKB)
Alt. Names/Synonyms: MGC:9349; RAF1B; RAFI63; RNA polymerase I-specific TBP-associated factor 63 kDa; SL1; SL1, 63kD subunit; TAF1B; TAFI63; TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa; TATA box-binding protein-associated factor 1B; TATA box-binding protein-associated factor RNA polymerase I subunit B; TBP-associated factor 1B; Transcription initiation factor SL1/TIF-IB subunit B
Gene Symbols: TAF1B
Molecular weight: 68,832 Da
Basal Isoelectric point: 8.27  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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