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Protein Page:
calreticulin 3

calreticulin 3 During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility. CALR3 capacity for calcium- binding may be absent or much lower than that of CALR. Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy type 19 (CMH19). CMH19 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Belongs to the calreticulin family. Note: This description may include information from UniProtKB.
Protein type: Cancer Testis Antigen (CTA); Chaperone
Chromosomal Location of Human Ortholog: 19p13.11
Cellular Component: endoplasmic reticulum lumen
Molecular Function: calcium ion binding; carbohydrate binding; unfolded protein binding
Biological Process: cell differentiation; protein folding; spermatogenesis
Disease: Cardiomyopathy, Familial Hypertrophic, 19
Reference #:  Q96L12 (UniProtKB)
Alt. Names/Synonyms: CALR3; calreticulin 2; calreticulin 3; Calreticulin-2; Calreticulin-3; cancer/testis antigen 93; CRT2; CT93; FLJ25355; MGC26577
Gene Symbols: CALR3
Molecular weight: 44,996 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
Select Structure to View Below

calreticulin 3

Protein Structure Not Found.

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