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Arg a cytoplasmic tyrosine kinase of the Abl family. Expressed at the highest levels in mature B cells. Promotes catalase degradation in the oxidative stress response. Localizes to dynamic actin structures and may regulate cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Abl family; EC; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of Human Ortholog: 1q25.2
Cellular Component: actin cytoskeleton; cytosol; extrinsic component of cytoplasmic side of plasma membrane
Molecular Function: actin filament binding; actin monomer binding; ATP binding; magnesium ion binding; manganese ion binding; non-membrane spanning protein tyrosine kinase activity; phosphotyrosine binding; protein binding; protein kinase activity; protein tyrosine kinase activity; receptor binding
Biological Process: cell adhesion; cellular protein modification process; cellular response to retinoic acid; elevation of cytosolic calcium ion concentration; innate immune response; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of neuron projection development; positive regulation of oxidoreductase activity; positive regulation of phospholipase C activity; regulation of actin cytoskeleton reorganization; regulation of autophagy; regulation of cell adhesion; regulation of cell motility; regulation of cell proliferation; regulation of endocytosis; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P42684 (UniProtKB)
Alt. Names/Synonyms: Abelson murine leukemia viral (v-abl) oncogene homolog 2; Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; ABL2; ABLL; ARG; arg tyrosine kinase; FLJ22224; FLJ31718; FLJ41441; Tyrosine-protein kinase ABL2; Tyrosine-protein kinase ARG; v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
Gene Symbols: ABL2
Molecular weight: 128,343 Da
Basal Isoelectric point: 8.31  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
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