Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

ERK2 a serine/threonine kinase of the GMGC group that plays a critical role in the regulation of cell growth and differentiation. ERK1 (MAPK3) and ERK2 (MAPK1) play central roles in MAPK cascades and are activated by a wide variety of extracellular signals including growth and neurotrophic factors, cytokines, hormones and neurotransmitters. Depending on the cellular context, MAPK cascades mediate diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. MAPK cascades also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. Activation of MAP kinases occurs through phosphorylation of threonine and tyrosine residues at the sequence T*EY* by upstream MAP kinase kinases, MEK1 and -2. Phosphorylation of both the threonine and tyrosine are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates. Note: This description may include information from UniProtKB.
Protein type: CMGC group; EC; ERK subfamily; Kinase, protein; MAPK family; MAPK/ERK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 22q11.22
Cellular Component: axon; caveola; cytoplasm; cytoskeleton; cytosol; dendrite cytoplasm; early endosome; extracellular exosome; extracellular region; ficolin-1-rich granule lumen; focal adhesion; Golgi apparatus; late endosome; microtubule organizing center; mitochondrion; nucleoplasm; nucleus; perikaryon; plasma membrane; protein complex; pseudopodium
Molecular Function: ATP binding; DNA binding; identical protein binding; kinase activity; MAP kinase activity; MAP kinase kinase activity; mitogen-activated protein kinase kinase kinase binding; phosphatase binding; phosphotyrosine binding; protein binding; protein serine/threonine kinase activity; RNA polymerase II carboxy-terminal domain kinase activity; transcription factor binding
Biological Process: activation of MAPK activity; apoptosis; axon guidance; B cell receptor signaling pathway; Bergmann glial cell differentiation; caveolin-mediated endocytosis; cell cycle; cellular response to amino acid starvation; cellular response to cadmium ion; cellular response to DNA damage stimulus; cellular response to reactive oxygen species; chemotaxis; cytosine metabolic process; diadenosine tetraphosphate biosynthetic process; ERBB signaling pathway; ERK1 and ERK2 cascade; Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; fibroblast growth factor receptor signaling pathway; learning and/or memory; lipopolysaccharide-mediated signaling pathway; mammary gland epithelial cell proliferation; MAPK cascade; negative regulation of cell differentiation; neutrophil degranulation; outer ear morphogenesis; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; platelet activation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of peptidyl-threonine phosphorylation; positive regulation of protein import into nucleus, translocation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; positive regulation of transcription, DNA-templated; positive regulation of translation; protein amino acid phosphorylation; regulation of cellular pH; regulation of cellular response to heat; regulation of cytoskeleton organization; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of ossification; regulation of phosphatidylinositol 3-kinase signaling; regulation of protein stability; regulation of stress-activated MAPK cascade; regulation of transcription factor activity; response to estrogen; response to exogenous dsRNA; response to nicotine; response to stress; response to toxin; sensory perception of pain; signal transduction; stress-activated MAPK cascade; synaptic transmission; T cell receptor signaling pathway; thymus development; thyroid gland development; transcription, DNA-dependent; viral process
Reference #:  P28482 (UniProtKB)
Alt. Names/Synonyms: ERK; ERK-2; ERK2; ERT1; Extracellular signal-regulated kinase 2; extracellular signal-regulated kinase-2; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAPK 1; MAPK 2; MAPK1; MAPK2; Mitogen-activated protein kinase 1; Mitogen-activated protein kinase 2; MK01; p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2; protein tyrosine kinase ERK2
Gene Symbols: MAPK1
Molecular weight: 41,390 Da
Basal Isoelectric point: 6.5  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

Substrate Sequence Logo
Sequence Logo

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein