Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

TBK1 a protein kinase of the IKK family. Can mediate NFkB activation in response to certain growth factors. Forms a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. Note: This description may include information from UniProtKB.
Protein type: EC; IKK family; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 12q14.2
Cellular Component: cytoplasm; cytosol; endosome membrane
Molecular Function: phosphoprotein binding; protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; inflammatory response; innate immune response; interferon type I production; negative regulation of interferon type I production; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon type I production; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of macroautophagy; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of interferon type I production; response to virus
Disease: Frontotemporal Dementia And/or Amyotrophic Lateral Sclerosis 4
Reference #:  Q9UHD2 (UniProtKB)
Alt. Names/Synonyms: FLJ11330; NAK; NF-kappa-B-activating kinase; NF-kB-activating kinase; Serine/threonine-protein kinase TBK1; T2K; TANK-binding kinase 1; TBK1
Gene Symbols: TBK1
Molecular weight: 83,642 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

Substrate Sequence Logo
Sequence Logo

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene