a serine/threonine-protein kinase of the STE20 family. Activates the p38 MAPK signaling pathway through the specific activation of the upstream kinases MKK3 and MKK6. A potential multi-pass membrane protein. Activated in the DNA damage response and regulates the G2/M transition DNA damage checkpoint. Interacts with tubulins through the C-terminal domain. Involved in apoptotic processes such as membrane blebbing and apoptotic body formation. Prevents TAK1-mediated activation of IKK-alpha, and thus NF-kappa-B activation. May play a role in the osmotic stress-JNK1 pathway. An autism spectrum disorder susceptibility gene. Affects basal dendrite formation and axonal projections in cortical pyramidal neurons. Interacts with NRP1 (neuropilin 1), a receptor for the secreted guidance protein semaphorin 3A (Sema3A). Influences the formation of basal dendrites through the activation of JNK. Three isoforms of the human protein are produced by alternative splicing. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Isoform 2 and kinase-defective, as well as full-length isoform 1 are excluded from the nucleus. Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC 220.127.116.11; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; TAO subfamily
Molecular Function: MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding; protein serine/threonine kinase activity
Biological Process: actin cytoskeleton organization and biogenesis; activation of MAPKK activity; focal adhesion formation; G2/M transition DNA damage checkpoint; nervous system development; positive regulation of JNK cascade; positive regulation of stress-activated MAPK cascade; regulation of apoptosis; regulation of cell shape; regulation of mitotic cell cycle; response to DNA damage stimulus; response to stress; stress-activated MAPK cascade