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CASK a MAGUK family protein and a protein kinase of the CAMK group. Contains one protein kinase domain, one guanylate kinase domain, two L27 domains, one PDZ domain and one SH3 domain. Plays a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Lacks the canonical DFG motif required for Mg++ binding, but retains protein kinase activity even without binding Mg++. Six alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; CAMK group; CASK family; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: Xp11.4
Cellular Component: actin cytoskeleton; basement membrane; basolateral plasma membrane; cytoplasm; cytosol; focal adhesion; intercellular junction; nuclear lamina; nuclear matrix; nucleolus; plasma membrane; presynaptic membrane; vesicle
Molecular Function: ATP binding; calmodulin binding; guanylate kinase activity; neurexin family protein binding; protein binding; protein serine/threonine kinase activity
Biological Process: cell adhesion; GDP metabolic process; GMP metabolic process; negative regulation of cell-matrix adhesion; negative regulation of cellular response to growth factor stimulus; negative regulation of keratinocyte proliferation; neurotransmitter secretion; positive regulation of calcium ion import; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation
Disease: Fg Syndrome 4; Mental Retardation And Microcephaly With Pontine And Cerebellar Hypoplasia
Reference #:  O14936 (UniProtKB)
Alt. Names/Synonyms: CAGH39; Calcium/calmodulin-dependent serine protein kinase; calcium/calmodulin-dependent serine protein kinase (MAGUK family); calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase; CAMGUK; CASK; CMG; CSKP; FGS4; FLJ22219; FLJ31914; hCASK; LIN2; MICPCH; Peripheral plasma membrane protein CASK; Protein lin-2 homolog; TNRC8; trinucleotide repeat containing 8
Gene Symbols: CASK
Molecular weight: 105,123 Da
Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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