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BMPR1B a kinase of the STKR family. A type I cell-surface receptor for bone morphogenetic protein. Expressed at ighest level in the prostate. May be upregulated by androgen stimulation in cells which expresses the androgen receptor. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type1 subfamily
Chromosomal Location of Human Ortholog: 4q22.3
Cellular Component: cell soma; dendrite; HFE-transferrin receptor complex; integral component of plasma membrane; plasma membrane; receptor complex
Molecular Function: ATP binding; metal ion binding; protein binding; protein serine/threonine kinase activity; signal transducer, downstream of receptor, with serine/threonine kinase activity; SMAD binding; transforming growth factor beta receptor activity, type I; transmembrane receptor protein serine/threonine kinase activity
Biological Process: BMP signaling pathway; cartilage condensation; cellular response to BMP stimulus; chondrocyte development; dorsal/ventral pattern formation; eye development; inflammatory response; limb morphogenesis; negative regulation of chondrocyte proliferation; ovarian cumulus expansion; ovulation cycle; positive regulation of bone mineralization; positive regulation of cell differentiation; positive regulation of chondrocyte differentiation; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; proteoglycan biosynthetic process; retina development in camera-type eye; retinal ganglion cell axon guidance; skeletal system development
Disease: Brachydactyly, Type A1, D; Brachydactyly, Type A2; Chondrodysplasia, Acromesomelic, With Genital Anomalies
Reference #:  O00238 (UniProtKB)
Alt. Names/Synonyms: activin receptor-like kinase 6; ALK-6; ALK6; BMP type-1B receptor; BMPR-1B; BMPR1B; BMR1B; Bone morphogenetic protein receptor type-1B; bone morphogenetic protein receptor, type IB; CDw293; serine/threonine receptor kinase
Gene Symbols: BMPR1B
Molecular weight: 56,930 Da
Basal Isoelectric point: 7.78  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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