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HIST2H3A/C/D Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer. Belongs to the histone H3 family. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 1q21.2
Cellular Component: extracellular region; nucleoplasm; nucleosome; nucleus
Molecular Function: histone binding; nucleosomal DNA binding; protein binding
Biological Process: blood coagulation; cellular protein metabolic process; chromatin silencing at rDNA; establishment and/or maintenance of chromatin architecture; negative regulation of gene expression, epigenetic; nucleosome assembly; positive regulation of gene expression, epigenetic
Reference #:  Q71DI3 (UniProtKB)
Alt. Names/Synonyms: H3 histone family, member M; H3 histone, family 2; histone 2, H3c; histone H3.2; histone H3/m; histone H3/o
Gene Symbols: HIST2H3A; HIST2H3C; HIST2H3D
Molecular weight: 15,388 Da
Basal Isoelectric point: 11.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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