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ALOX5AP Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition. Belongs to the MAPEG family. Note: This description may include information from UniProtKB.
Protein type: Activator; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Nuclear envelope
Chromosomal Location of Human Ortholog: 13q12.3
Cellular Component: endoplasmic reticulum; membrane; nuclear envelope; nuclear membrane
Molecular Function: arachidonic acid binding; glutathione peroxidase activity; glutathione transferase activity; leukotriene-C4 synthase activity; protein binding; protein N-terminus binding
Biological Process: leukotriene biosynthetic process; leukotriene metabolic process; lipoxygenase pathway
Disease: Stroke, Ischemic
Reference #:  P20292 (UniProtKB)
Alt. Names/Synonyms: AL5AP; ALOX5AP; Arachidonate 5-lipoxygenase-activating protein; FLAP; MK-886-binding protein
Gene Symbols: ALOX5AP
Molecular weight: 18,157 Da
Basal Isoelectric point: 8.58  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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