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NUDT10 Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Belongs to the Nudix hydrolase family. DIPP subfamily. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Hydrolase
Chromosomal Location of Human Ortholog: Xp11.22
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: diphosphoinositol-polyphosphate diphosphatase activity; endopolyphosphatase activity; m7G(5')pppN diphosphatase activity; metal ion binding; protein binding
Biological Process: inositol phosphate metabolic process
Reference #:  Q8NFP7 (UniProtKB)
Alt. Names/Synonyms: APS2; Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alpha; Diphosphoinositol polyphosphate phosphohydrolase 3-alpha; diphosphoinositol polyphosphate phosphohydrolase type 3 alpha; DIPP-3-alpha; DIPP3-alpha; DIPP3A; hAps2; hDIPP3alpha; Nucleoside diphosphate-linked moiety X motif 10; NUD10; nudix (nucleoside diphosphate linked moiety X)-type motif 10; Nudix motif 10; NUDT10
Gene Symbols: NUDT10
Molecular weight: 18,500 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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