Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene. Belongs to the type II topoisomerase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; DNA-binding; EC 184.108.40.206; Motility/polarity/chemotaxis; Nucleolus; Topoisomerase
Molecular Function: chromatin binding; DNA topoisomerase (ATP-hydrolyzing) activity; enzyme binding; histone deacetylase binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein kinase C binding; ribonucleoprotein binding
Biological Process: axonogenesis; DNA topological change; forebrain development; neuron migration; resolution of meiotic joint molecules as recombinants; sister chromatid segregation