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TOP2B Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene. Belongs to the type II topoisomerase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; DNA-binding; EC; Motility/polarity/chemotaxis; Nucleolus; Topoisomerase
Chromosomal Location of Human Ortholog: 14|14 A2
Cellular Component: chromosome; cytosol; heterochromatin; nucleoplasm; nucleus
Molecular Function: chromatin binding; DNA topoisomerase (ATP-hydrolyzing) activity; enzyme binding; histone deacetylase binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein kinase C binding; ribonucleoprotein binding
Biological Process: axonogenesis; DNA topological change; forebrain development; neuron migration; resolution of meiotic joint molecules as recombinants; sister chromatid segregation
Reference #:  Q64511 (UniProtKB)
Alt. Names/Synonyms: D230016L12Rik; DNA topoisomerase 2-beta; DNA topoisomerase II, beta isozyme; Top-2; Top2b; topoisomerase (DNA) II beta
Gene Symbols: Top2b
Molecular weight: 181,909 Da
Basal Isoelectric point: 8.46  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint
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Protein Structure Not Found.
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