Transcriptional activator that regulates SEMA3C and PLXNA2. Thought to be important for regulating terminal differentiation and/or proliferation. Interacts with LMCD1. Expressed in heart, gut and gut-derived tissues. 2 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Transcription factor
Molecular Function: chromatin binding; DNA binding transcription factor activity; protein binding; protein kinase binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; transcription factor binding; zinc ion binding
Biological Process: animal organ formation; blood coagulation; cardiac muscle cell differentiation; cardiac muscle hypertrophy in response to stress; cellular protein metabolic process; endodermal cell fate determination; in utero embryonic development; liver development; male gonad development; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta1 production; negative regulation of transforming growth factor-beta2 production; phospholipid metabolic process; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; positive regulation of cardiac muscle cell proliferation; positive regulation of cardioblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; response to drug; response to estrogen; smooth muscle cell differentiation; transcription from RNA polymerase II promoter; tube morphogenesis