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GATA6 Transcriptional activator that regulates SEMA3C and PLXNA2. Thought to be important for regulating terminal differentiation and/or proliferation. Interacts with LMCD1. Expressed in heart, gut and gut-derived tissues. 2 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Transcription factor
Chromosomal Location of Human Ortholog: 18q11.2
Cellular Component: nuclear membrane; nucleoplasm; nucleus; transcription factor complex
Molecular Function: chromatin binding; DNA binding transcription factor activity; protein binding; protein kinase binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; transcription factor binding; zinc ion binding
Biological Process: animal organ formation; blood coagulation; cardiac muscle cell differentiation; cardiac muscle hypertrophy in response to stress; cellular protein metabolic process; endodermal cell fate determination; in utero embryonic development; liver development; male gonad development; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta1 production; negative regulation of transforming growth factor-beta2 production; phospholipid metabolic process; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; positive regulation of cardiac muscle cell proliferation; positive regulation of cardioblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; response to drug; response to estrogen; smooth muscle cell differentiation; transcription from RNA polymerase II promoter; tube morphogenesis
Disease: Atrial Septal Defect 9; Atrioventricular Septal Defect 5; Conotruncal Heart Malformations; Heart Defects, Congenital, And Other Congenital Anomalies; Tetralogy Of Fallot
Reference #:  Q92908 (UniProtKB)
Alt. Names/Synonyms: GATA binding protein 6; GATA-binding factor 6; GATA-binding protein 6; GATA6; Transcription factor GATA-6
Gene Symbols: GATA6
Molecular weight: 60,033 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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