a dual-specificity protein kinase orthologous to the yeast monopolar spindle (Mps1) kinase that is required for spindle pole duplication and the spindle checkpoint but not for centrosome duplication. Localized to centrosomes, kinetochores and nuclear pores. Its enzymatic activity is required for the recruitment of Mad1, Mad2, Bub1 and Bub3 to the kinetochore. Mps1 mRNA levels change little throughout the cell cycle, but its protein expression varies during the cell cycle. Overexpression arrests cells in metaphase by activating the checkpoint. Note: This description may include information from UniProtKB.
Protein type: Cancer Testis Antigen (CTA); EC 126.96.36.199; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor); TTK family
Molecular Function: ATP binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity
Biological Process: chromosome separation; female meiosis chromosome segregation; meiotic spindle assembly checkpoint; mitotic cell cycle spindle assembly checkpoint; mitotic spindle organization and biogenesis; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of cell proliferation; positive regulation of pathway-restricted SMAD protein phosphorylation; protein autophosphorylation; protein localization to kinetochore; spindle organization and biogenesis