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ARPC2 Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament. Belongs to the ARPC2 family. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: actin cytoskeleton; Arp2/3 protein complex; cytosol; focal adhesion
Molecular Function: actin filament binding; protein binding; structural constituent of cytoskeleton
Biological Process: cell motility; ephrin receptor signaling pathway
Reference #:  O15144 (UniProtKB)
Alt. Names/Synonyms: actin related protein 2/3 complex, subunit 2, 34kDa; Actin-related protein 2/3 complex subunit 2; ARC34; Arp2/3 complex 34 kDa subunit; ARP2/3 protein complex subunit 34; ARPC2; p34-ARC; PNAS-139; PRO2446
Gene Symbols: ARPC2
Molecular weight: 34,333 Da
Basal Isoelectric point: 6.84  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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