Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

CDKL5 a protein kinase of the CDKL family. Mutations have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. Note: This description may include information from UniProtKB.
Protein type: CDKL family; CMGC group; Cell cycle regulation; EC; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: Xp22.13
Cellular Component: cytosol; dendrite cytoplasm; dendritic growth cone; nucleoplasm; nucleus; perinuclear region of cytoplasm; synapse
Molecular Function: ATP binding; cyclin-dependent protein kinase activity; kinase activity; protein kinase activity; protein serine/threonine kinase activity; Rac GTPase binding
Biological Process: neuron migration; positive regulation of axon extension; positive regulation of dendrite morphogenesis; positive regulation of GTPase activity; protein amino acid phosphorylation; protein autophosphorylation; regulation of dendrite development
Disease: Epileptic Encephalopathy, Early Infantile, 2
Reference #:  O76039 (UniProtKB)
Alt. Names/Synonyms: CDKL5; Cyclin-dependent kinase-like 5; ISSX; serine/threonine kinase 9; Serine/threonine-protein kinase 9; STK9
Gene Symbols: CDKL5
Molecular weight: 115,538 Da
Basal Isoelectric point: 9.58  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein