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ACTC1 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Belongs to the actin family. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Contractile; Cytoskeletal; Motility/polarity/chemotaxis; Myosin-binding
Chromosomal Location of Human Ortholog: 15q14
Cellular Component: actin filament; cytoplasm; cytosol; extracellular space; filopodium; focal adhesion; I band; lamellipodium; membrane; sarcomere
Molecular Function: ATP binding; ATPase activity; myosin binding
Biological Process: actin filament-based movement; actin-myosin filament sliding; actomyosin structure organization and biogenesis; apoptosis; cardiac muscle morphogensis; cardiac myofibril assembly; heart contraction; muscle filament sliding; muscle thin filament assembly
Disease: Atrial Septal Defect 5; Cardiomyopathy, Dilated, 1r; Cardiomyopathy, Familial Hypertrophic, 11
Reference #:  P68032 (UniProtKB)
Alt. Names/Synonyms: ACTC; ACTC1; Actin, alpha cardiac muscle 1; actin, alpha, cardiac muscle 1; Alpha-cardiac actin; ASD5; CMD1R; CMH11
Gene Symbols: ACTC1
Molecular weight: 42,019 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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