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PLK4 a kinase of the PLK family. Localizes to centrosomes and the cleavage furrow during cytokinesis. Interacts with the protein kinase Tec. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Nucleolus; Other group; PLK family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 4q28.1
Cellular Component: centriole; centrosome; cleavage furrow; cytosol; deuterosome; nucleolus; XY body
Molecular Function: ATP binding; identical protein binding; protein binding; protein serine/threonine kinase activity
Biological Process: centriole replication; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation; G2/M transition of mitotic cell cycle; positive regulation of centriole replication; protein amino acid phosphorylation; regulation of G2/M transition of mitotic cell cycle
Disease: Microcephaly And Chorioretinopathy, Autosomal Recessive, 2
Reference #:  O00444 (UniProtKB)
Alt. Names/Synonyms: PLK-4; PLK4; Polo-like kinase 4; polo-like kinase 4 (Drosophila); SAK; serine/threonine kinase 18; serine/threonine protein kinase SAK; Serine/threonine-protein kinase 18; Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase Sak; Snk akin kinase; STK18
Gene Symbols: PLK4
Molecular weight: 108,972 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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