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TRPC6 Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. Interacts with MX1 and RNF24. Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11q22.1
Cellular Component: cytoplasm; integral to plasma membrane; membrane; plasma membrane
Molecular Function: calcium channel activity; protein binding; store-operated calcium channel activity
Biological Process: cation transport; cytosolic calcium ion homeostasis; manganese ion transport; platelet activation; positive regulation of calcium ion transport; positive regulation of ion transmembrane transporter activity; single fertilization
Disease: Focal Segmental Glomerulosclerosis 2
Reference #:  Q9Y210 (UniProtKB)
Alt. Names/Synonyms: FLJ11098; FLJ14863; FSGS2; Short transient receptor potential channel 6; transient receptor potential cation channel, subfamily C, member 6; Transient receptor protein 6; TRP-6; TRP6; TRPC6
Gene Symbols: TRPC6
Molecular weight: 106,326 Da
Basal Isoelectric point: 6.24  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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