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PTGES Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Belongs to the MAPEG family. Note: This description may include information from UniProtKB.
Protein type: EC; Isomerase; Lipid Metabolism - arachidonic acid; Membrane protein, integral; Membrane protein, multi-pass; Nuclear envelope
Chromosomal Location of Human Ortholog: 2 B|2 21.75 cM
Cellular Component: cytoplasm; integral to membrane; intracellular membrane-bound organelle; nuclear envelope lumen; nucleus; perinuclear region of cytoplasm
Molecular Function: glutathione binding; prostaglandin-D synthase activity; prostaglandin-E synthase activity
Biological Process: negative regulation of cell proliferation; prostaglandin biosynthetic process; prostaglandin metabolic process
Reference #:  Q9JM51 (UniProtKB)
Alt. Names/Synonyms: 2410099E23Rik; D2Ertd369e; mPGES; mPGES-1; OTTMUSP00000012699; Pges; Prostaglandin E synthase; Ptges
Gene Symbols: Ptges
Molecular weight: 17,286 Da
Basal Isoelectric point: 9.47  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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