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PLA2G2E PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids. Belongs to the phospholipase A2 family. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1p36.13
Cellular Component: extracellular region
Molecular Function: calcium ion binding; phospholipase A2 activity
Biological Process: arachidonic acid secretion; inflammatory response; lipid catabolic process; phosphatidic acid biosynthetic process; phospholipid metabolic process
Reference #:  Q9NZK7 (UniProtKB)
Alt. Names/Synonyms: GIIE sPLA2; Group IIE secretory phospholipase A2; PA2GE; Phosphatidylcholine 2-acylhydrolase 2E; phospholipase A2, group IIE; PLA2G2E; sPLA2-IIE
Gene Symbols: PLA2G2E
Molecular weight: 15,989 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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