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ACER3 Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity. Belongs to the alkaline ceramidase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.5.1.-; Hydrolase; Lipid Metabolism - sphingolipid; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11q13.5
Cellular Component: endoplasmic reticulum membrane; integral component of endoplasmic reticulum membrane; integral to Golgi membrane
Biological Process: ceramide metabolic process; positive regulation of cell proliferation; sphingolipid biosynthetic process; sphingosine biosynthetic process
Reference #:  Q9NUN7 (UniProtKB)
Alt. Names/Synonyms: ACER3; Alkaline CDase 3; Alkaline ceramidase 3; Alkaline dihydroceramidase SB89; Alkaline phytoceramidase; AlkCDase 3; APHC; FLJ11238; PHCA; phytoceramidase, alkaline
Gene Symbols: ACER3
Molecular weight: 31,552 Da
Basal Isoelectric point: 8.87  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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