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PLA2G2D PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2- linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined. Belongs to the phospholipase A2 family. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1p36.12
Cellular Component: extracellular region
Molecular Function: calcium ion binding; heparan sulfate proteoglycan binding; heparin binding; phospholipase A2 activity
Biological Process: arachidonic acid secretion; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; inflammatory response; lipid catabolic process; negative regulation of T cell proliferation; phosphatidic acid biosynthetic process; phospholipid metabolic process
Reference #:  Q9UNK4 (UniProtKB)
Alt. Names/Synonyms: GIID sPLA2; Group IID secretory phospholipase A2; PA2GD; Phosphatidylcholine 2-acylhydrolase 2D; phospholipase A2, group IID; PLA2G2D; PLA2IID; secretory phospholipase A2s; Secretory-type PLA, stroma-associated homolog; sPLA2-IID; sPLA2S; SPLASH
Gene Symbols: PLA2G2D
Molecular weight: 16,546 Da
Basal Isoelectric point: 8.6  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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