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osteopontin Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Belongs to the osteopontin family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q22.1
Cellular Component: endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi apparatus
Molecular Function: extracellular matrix binding; protein binding
Biological Process: androgen catabolic process; cell adhesion; cellular protein metabolic process; decidualization; embryo implantation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; osteoblast differentiation; positive regulation of bone resorption; positive regulation of transcription, DNA-dependent; post-translational protein modification; response to vitamin D
Reference #:  P10451 (UniProtKB)
Alt. Names/Synonyms: BNSP; Bone sialoprotein 1; bone sialoprotein I; BSPI; early T-lymphocyte activation 1; ETA-1; MGC110940; Nephropontin; OPN; Osteopontin; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; OSTP; Secreted phosphoprotein 1; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1); secreted phosphoprotein-1 (osteopontin, bone sialoprotein); SPP-1; SPP1; SPP1/CALPHA1 fusion; Urinary stone protein; Uropontin
Gene Symbols: SPP1
Molecular weight: 35,423 Da
Basal Isoelectric point: 4.37  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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