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Protein Page:
USP46

Overview
USP46 Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2. Belongs to the peptidase C19 family. USP12/USP46 subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.19.12; Protease; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 4q12
Molecular Function: protein binding; ubiquitin-specific protease activity
Biological Process: protein deubiquitination; regulation of synaptic transmission, GABAergic
Reference #:  P62068 (UniProtKB)
Alt. Names/Synonyms: Deubiquitinating enzyme 46; FLJ11850; FLJ12552; FLJ14283; FLJ39393; Ubiquitin carboxyl-terminal hydrolase 46; ubiquitin specific peptidase 46; ubiquitin specific protease 46; Ubiquitin thioesterase 46; Ubiquitin-specific-processing protease 46; UBP46; USP46
Gene Symbols: USP46
Molecular weight: 42,442 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
Select Structure to View Below

USP46

Protein Structure Not Found.
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