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GPX1 Protects the hemoglobin in erythrocytes from oxidative breakdown. Homotetramer. Interacts with MIEN1. Belongs to the glutathione peroxidase family. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - arachidonic acid; Other Amino Acids Metabolism - glutathione; Oxidoreductase
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: cytoplasm; cytosol; mitochondrial matrix; mitochondrion
Molecular Function: glutathione peroxidase activity; SH3 domain binding
Biological Process: cell redox homeostasis; glutathione metabolic process; heart contraction; hydrogen peroxide catabolic process; lipoxygenase pathway; negative regulation of caspase activity; purine nucleotide catabolic process; regulation of gene expression, epigenetic; regulation of mammary gland epithelial cell proliferation; response to hydrogen peroxide; response to selenium ion; UV protection
Disease: Glutathione Peroxidase Deficiency
Reference #:  P07203 (UniProtKB)
Alt. Names/Synonyms: Cellular glutathione peroxidase; Glutathione peroxidase 1; GPx-1; GPX1; GSHPx-1; GSHPX1; MGC14399; MGC88245
Gene Symbols: GPX1
Molecular weight: 22,088 Da
Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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