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Protein Page:

RIPK3 Promotes apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; RIPK family; TKL group
Chromosomal Location of Human Ortholog: 14q12
Cellular Component: cytosol; mitochondrion; plasma membrane
Molecular Function: ATP binding; identical protein binding; NF-kappaB-inducing kinase activity; protein binding; protein complex binding; protein kinase activity; protein serine/threonine kinase activity; transcription coactivator activity
Biological Process: activation of protein kinase activity; amyloid fibril formation; cellular protein modification process; I-kappaB kinase/NF-kappaB signaling; lymph node development; necroptotic process; NIK/NF-kappaB signaling; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of ligase activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of oxidoreductase activity; positive regulation of phosphatase activity; positive regulation of protein deacetylation; positive regulation of reactive oxygen species metabolic process; protein autophosphorylation; protein heterooligomerization; protein homooligomerization; regulation of activated T cell proliferation; regulation of adaptive immune response; regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; regulation of interferon-gamma production; regulation of T cell mediated cytotoxicity; signal transduction; spleen development; T cell differentiation in thymus; T cell homeostasis; thymus development
Reference #:  Q9Y572 (UniProtKB)
Alt. Names/Synonyms: receptor interacting protein 3; Receptor-interacting protein 3; receptor-interacting serine-threonine kinase 3; Receptor-interacting serine/threonine-protein kinase 3; RIP-3; RIP-like protein kinase 3; RIP3; RIPK3
Gene Symbols: RIPK3
Molecular weight: 56,887 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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