Promotes apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 22.214.171.124; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; RIPK family; TKL group
Molecular Function: ATP binding; identical protein binding; NF-kappaB-inducing kinase activity; protein binding; protein complex binding; protein kinase activity; protein serine/threonine kinase activity; transcription coactivator activity
Biological Process: activation of protein kinase activity; amyloid fibril formation; cellular protein modification process; I-kappaB kinase/NF-kappaB signaling; lymph node development; necroptotic process; NIK/NF-kappaB signaling; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of ligase activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of oxidoreductase activity; positive regulation of phosphatase activity; positive regulation of protein deacetylation; positive regulation of reactive oxygen species metabolic process; protein autophosphorylation; protein heterooligomerization; protein homooligomerization; regulation of activated T cell proliferation; regulation of adaptive immune response; regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; regulation of interferon-gamma production; regulation of T cell mediated cytotoxicity; signal transduction; spleen development; T cell differentiation in thymus; T cell homeostasis; thymus development