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RIPK2 a tyrosine kinase-like kinase of the RIPK family. Activates pro-caspase-1 and pro-caspase-8. Potentiates casp-8-mediated apoptosis. May activate NF-kappaB. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; RIPK family; TKL group
Chromosomal Location of Human Ortholog: 8q21.3
Cellular Component: cytoplasm; cytoskeleton; cytosol; protein complex; vesicle
Molecular Function: ATP binding; CARD domain binding; caspase binding; identical protein binding; LIM domain binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; receptor binding; signal transducer activity
Biological Process: activation of MAPK activity; adaptive immune response; apoptosis; defense response to Gram-positive bacterium; I-kappaB kinase/NF-kappaB signaling; inflammatory response; innate immune response; JNK cascade; lipopolysaccharide-mediated signaling pathway; MAPK cascade; negative regulation of apoptosis; nucleotide-binding oligomerization domain containing 1 signaling pathway; nucleotide-binding oligomerization domain containing 2 signaling pathway; nucleotide-binding oligomerization domain containing signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of alpha-beta T cell proliferation; positive regulation of apoptosis; positive regulation of cell death; positive regulation of chemokine production; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of immature T cell proliferation; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of interferon-gamma production; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-12 production; positive regulation of interleukin-2 production; positive regulation of interleukin-6 production; positive regulation of JNK cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein binding; positive regulation of protein ubiquitination; positive regulation of T-helper 1 cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; positive regulation of xenophagy; protein deubiquitination; response to exogenous dsRNA; signal transduction; T cell proliferation; T cell receptor signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway
Reference #:  O43353 (UniProtKB)
Alt. Names/Synonyms: CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD3; CARDIAK; CCK; GIG30; growth-inhibiting gene 30; receptor interacting protein 2; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; Receptor-interacting protein 2; receptor-interacting serine-threonine kinase 2; Receptor-interacting serine/threonine-protein kinase 2; RICK; RIP-2; RIP-like-interacting CLARP kinase; RIP2; RIPK2
Gene Symbols: RIPK2
Molecular weight: 61,195 Da
Basal Isoelectric point: 6.63  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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