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AEBP1 May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I- kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. Belongs to the peptidase M14 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide; Transcription factor
Chromosomal Location of Human Ortholog: 7p13
Cellular Component: cytoplasm; extracellular matrix; extracellular region; extracellular space; nucleus
Molecular Function: calmodulin binding; carboxypeptidase activity; DNA binding transcription factor activity; metallocarboxypeptidase activity; serine carboxypeptidase activity; transcription corepressor activity; zinc ion binding
Biological Process: muscle organ development; negative regulation of transcription from RNA polymerase II promoter; peptide metabolic process; protein processing; skeletal system development; transcription, DNA-dependent
Reference #:  Q8IUX7 (UniProtKB)
Alt. Names/Synonyms: ACLP; adipocyte enhancer binding protein 1; Adipocyte enhancer-binding protein 1; AE binding protein 1; AE-binding protein 1; AEBP1; Aortic carboxypeptidase-like protein; FLJ33612
Gene Symbols: AEBP1
Molecular weight: 130,929 Da
Basal Isoelectric point: 5.05  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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