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Protein Page:
G-beta 3

G-beta 3 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. G proteins are composed of 3 units, alpha, beta and gamma. Interacts with RASD2. Belongs to the WD repeat G protein beta family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric beta
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component: cytosol; plasma membrane
Molecular Function: GTPase activity; GTPase binding; protein binding
Biological Process: G-protein coupled receptor protein signaling pathway; protein folding; regulation of blood pressure
Disease: Hypertension, Essential; Night Blindness, Congenital Stationary, Type 1h
Reference #:  P16520 (UniProtKB)
Alt. Names/Synonyms: G protein, beta-3 subunit; GBB3; GNB3; GTP-binding regulatory protein beta-3 chain; guanine nucleotide binding protein (G protein), beta polypeptide 3; guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; hypertension associated protein; Transducin beta chain 3
Gene Symbols: GNB3
Molecular weight: 37,221 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Parkinson's Disease  |  Phospholipase Signaling  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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G-beta 3

Protein Structure Not Found.

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