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WAVE2 Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with BRK1. Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle. Belongs to the SCAR/WAVE family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component: actin cytoskeleton; cytosol; early endosome; intercellular junction; intracellular; lamellipodium; protein complex; ruffle
Molecular Function: actin binding; cadherin binding; protein binding; protein complex binding; protein kinase A binding; SH3 domain binding
Biological Process: actin cytoskeleton organization; actin filament-based movement; ameboidal cell migration; angiogenesis; G-protein signaling, coupled to cAMP nucleotide second messenger; lamellipodium assembly; negative regulation of stress fiber formation; Rac protein signal transduction; vascular endothelial growth factor receptor signaling pathway; viral process
Reference #:  Q9Y6W5 (UniProtKB)
Alt. Names/Synonyms: dJ393P12.2; IMD2; Protein WAVE-2; SCAR2; suppressor of cyclic-AMP receptor (WASP-family); Verprolin homology domain-containing protein 2; WAS protein family, member 2; WASF2; WASP family protein member 2; WASP family Verprolin-homologous protein 2; WAVE2; Wiskott-Aldrich syndrome protein family member 2
Gene Symbols: WASF2
Molecular weight: 54,284 Da
Basal Isoelectric point: 5.38  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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