a member of the MAPKAPK family of protein kinases. Activated through phosphorylation by MAP kinases including ERK, p38-alpha, and MAPp38-beta In response to cellular stress and proinflammatory cytokines. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; EC 184.108.40.206; Kinase, protein; MAPKAPK family; MAPKAPK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; protein complex
Molecular Function: calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; mitogen-activated protein kinase binding; p53 binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; signal transducer activity
Biological Process: cell surface receptor linked signal transduction; MAPKKK cascade; negative regulation of TOR signaling pathway; peptidyl-serine phosphorylation; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; protein amino acid autophosphorylation; Ras protein signal transduction; regulation of translation