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PIK3C3 Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes. Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4. Forms a complex with BECN1, PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. In this complex, presence of UVRAG and ATG14 are mutually exclusive. Part of a complex composed of PIK3R4 and PIK3CB. Interacts with RAB7A in the presence of PIK3R4. Ubiquitously expressed, with a highest expression in skeletal muscle. Belongs to the PI3/PI4-kinase family. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Carbohydrate Metabolism - inositol phosphate; EC; Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 18|18 B1
Cellular Component: cytoplasmic vesicle; endosome; late endosome; membrane; midbody; peroxisome; phagocytic vesicle
Molecular Function: 1-phosphatidylinositol-3-kinase activity; ATP binding; kinase activity; nucleotide binding; phosphoinositide 3-kinase activity; protein binding; protein kinase activity; transferase activity
Biological Process: autophagosome assembly; autophagy; autophagy of peroxisome; cell cycle; cell division; cellular response to glucose starvation; cellular response to starvation; cytokinesis; early endosome to late endosome transport; endocytosis; endosomal transport; endosome organization and biogenesis; macroautophagy; phosphatidylinositol phosphorylation; phosphoinositide-mediated signaling; phosphorylation; protein amino acid phosphorylation; protein lipidation; protein processing; regulation of cytokinesis; regulation of protein secretion
Reference #:  Q6PF93 (UniProtKB)
Alt. Names/Synonyms: 5330434F23Rik; OTTMUSP00000023341; Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphoinositide-3-kinase class 3; phosphoinositide-3-kinase, class 3; PI3-kinase type 3; PI3K type 3; Pik3c3; PK3C3; PtdIns-3-kinase type 3; Vps34
Gene Symbols: Pik3c3
Molecular weight: 101,487 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  Autophagy Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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