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MAPKAPK2 a member of the MAPKAPK family of protein kinases. It is phosphorylated and activated by p38 in response to cytokines, stress and chemotactic factors.MAPKAPK-2 is apparently a direct target of p38 MAPK. HSP27 is one of its in vivo substrates. Two transcript variants encoding two different isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: CAMK group; EC; Kinase, protein; MAPKAPK family; MAPKAPK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: centrosome; cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; mitogen-activated protein kinase binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; signal transducer activity
Biological Process: activation of MAPK activity; G2/M transition DNA damage checkpoint; inflammatory response; leukotriene metabolic process; MAPKKK cascade; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; Ras protein signal transduction; regulation of interleukin-6 production; regulation of mRNA stability; regulation of tumor necrosis factor production; response to cytokine stimulus; response to DNA damage stimulus; response to lipopolysaccharide; response to stress; toll-like receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway
Reference #:  P49137 (UniProtKB)
Alt. Names/Synonyms: MAP kinase-activated protein kinase 2; MAPK-activated protein kinase 2; MAPK2; MAPKAP kinase 2; MAPKAPK-2; MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2; MK2
Gene Symbols: MAPKAPK2
Molecular weight: 45,568 Da
Basal Isoelectric point: 8.87  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Microtubule Dynamics  |  Regulation of P38 MAPKs
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